Threonyl-tRNA Synthetase Promotes T Helper Type 1 Cell Responses by Inducing Dendritic Cell Maturation and IL-12 Production via an NF-κB Pathway

Threonyl-tRNA Synthetase Promotes T Helper Type 1 Cell Responses by Inducing Dendritic Cell Maturation and IL-12 Production via an NF-κB Pathway

Threonyl-tRNA synthetase (TRS) is an aminoacyl-tRNA synthetase that catalyzes the aminoacylation of tRNA by transferring threonine. In addition to an essential role in translation, TRS was extracellularly detected in autoimmune diseases and also exhibited pro-angiogenetic activity. TRS is reported t...

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Bibliographic Details
Main Authors: Hak-Jun Jung, Su-Ho Park, Kyung-Min Cho, Kwang Il Jung, Daeho Cho, Tae Sung Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
aminoacyl-tRNA synthetase
threonyl-tRNA synthetase
dendritic cell
interleukin-12
type 1 helper T cells
interferon-γ
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.571959/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.571959/full

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