Mystery of fatal ‘staggering disease’ unravelled: novel rustrela virus causes severe meningoencephalomyelitis in domestic cats
Rustrela virus (RusV) was detected in the brains of 27 out of 29 domestic cats with ‘staggering disease’, but not of 29 control cats. This suggests RusV as the long-sought causative agent of ‘staggering disease’, which had been obscure for 50 years.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36204-w |
| _version_ | 1811171626706796544 |
|---|---|
| author | Kaspar Matiasek Florian Pfaff Herbert Weissenböck Claudia Wylezich Jolanta Kolodziejek Sofia Tengstrand Frauke Ecke Sina Nippert Philip Starcky Benedikt Litz Jasmin Nessler Peter Wohlsein Christina Baumbach Lars Mundhenk Andrea Aebischer Sven Reiche Pia Weidinger Karin M. Olofsson Cecilia Rohdin Christiane Weissenbacher-Lang Julia Matt Marco Rosati Thomas Flegel Birger Hörnfeldt Dirk Höper Rainer G. Ulrich Norbert Nowotny Martin Beer Cecilia Ley Dennis Rubbenstroth |
| author_facet | Kaspar Matiasek Florian Pfaff Herbert Weissenböck Claudia Wylezich Jolanta Kolodziejek Sofia Tengstrand Frauke Ecke Sina Nippert Philip Starcky Benedikt Litz Jasmin Nessler Peter Wohlsein Christina Baumbach Lars Mundhenk Andrea Aebischer Sven Reiche Pia Weidinger Karin M. Olofsson Cecilia Rohdin Christiane Weissenbacher-Lang Julia Matt Marco Rosati Thomas Flegel Birger Hörnfeldt Dirk Höper Rainer G. Ulrich Norbert Nowotny Martin Beer Cecilia Ley Dennis Rubbenstroth |
| author_sort | Kaspar Matiasek |
| collection | DOAJ |
| description | Rustrela virus (RusV) was detected in the brains of 27 out of 29 domestic cats with ‘staggering disease’, but not of 29 control cats. This suggests RusV as the long-sought causative agent of ‘staggering disease’, which had been obscure for 50 years. |
| first_indexed | 2024-04-10T17:17:13Z |
| format | Article |
| id | doaj.art-62200dd9690847e48acb3aa0c5d6c8a7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T17:17:13Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-62200dd9690847e48acb3aa0c5d6c8a72023-02-05T12:18:20ZengNature PortfolioNature Communications2041-17232023-02-0114111410.1038/s41467-023-36204-wMystery of fatal ‘staggering disease’ unravelled: novel rustrela virus causes severe meningoencephalomyelitis in domestic catsKaspar Matiasek0Florian Pfaff1Herbert Weissenböck2Claudia Wylezich3Jolanta Kolodziejek4Sofia Tengstrand5Frauke Ecke6Sina Nippert7Philip Starcky8Benedikt Litz9Jasmin Nessler10Peter Wohlsein11Christina Baumbach12Lars Mundhenk13Andrea Aebischer14Sven Reiche15Pia Weidinger16Karin M. Olofsson17Cecilia Rohdin18Christiane Weissenbacher-Lang19Julia Matt20Marco Rosati21Thomas Flegel22Birger Hörnfeldt23Dirk Höper24Rainer G. Ulrich25Norbert Nowotny26Martin Beer27Cecilia Ley28Dennis Rubbenstroth29Section of Clinical & Comparative Neuropathology, Institute of Veterinary Pathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universitaet-MuenchenInstitute of Diagnostic Virology, Friedrich-Loeffler-InstitutInstitute of Pathology, University of Veterinary Medicine ViennaInstitute of Diagnostic Virology, Friedrich-Loeffler-InstitutInstitute of Virology, University of Veterinary Medicine ViennaDepartment of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences (SLU)Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences (SLU)Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-InstitutInstitute of Diagnostic Virology, Friedrich-Loeffler-InstitutInstitute of Diagnostic Virology, Friedrich-Loeffler-InstitutDepartment of Small Animal Medicine and Surgery, University of Veterinary Medicine HannoverDepartment of Pathology, University of Veterinary Medicine HannoverState Office for Agriculture, Food Safety and FisheriesInstitute of Veterinary Pathology, Freie Universität BerlinDepartment of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-InstitutDepartment of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-InstitutInstitute of Virology, University of Veterinary Medicine ViennaDepartment of Pathology and Wildlife Diseases, National Veterinary Institute (SVA)Department of Clinical Sciences, Swedish University of Agricultural Sciences (SLU)Institute of Pathology, University of Veterinary Medicine ViennaInstitute of Pathology, University of Veterinary Medicine ViennaSection of Clinical & Comparative Neuropathology, Institute of Veterinary Pathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universitaet-MuenchenDepartment of Small Animal Medicine, Leipzig UniversityDepartment of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences (SLU)Institute of Diagnostic Virology, Friedrich-Loeffler-InstitutInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-InstitutInstitute of Virology, University of Veterinary Medicine ViennaInstitute of Diagnostic Virology, Friedrich-Loeffler-InstitutDepartment of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences (SLU)Institute of Diagnostic Virology, Friedrich-Loeffler-InstitutRustrela virus (RusV) was detected in the brains of 27 out of 29 domestic cats with ‘staggering disease’, but not of 29 control cats. This suggests RusV as the long-sought causative agent of ‘staggering disease’, which had been obscure for 50 years.https://doi.org/10.1038/s41467-023-36204-w |
| spellingShingle | Kaspar Matiasek Florian Pfaff Herbert Weissenböck Claudia Wylezich Jolanta Kolodziejek Sofia Tengstrand Frauke Ecke Sina Nippert Philip Starcky Benedikt Litz Jasmin Nessler Peter Wohlsein Christina Baumbach Lars Mundhenk Andrea Aebischer Sven Reiche Pia Weidinger Karin M. Olofsson Cecilia Rohdin Christiane Weissenbacher-Lang Julia Matt Marco Rosati Thomas Flegel Birger Hörnfeldt Dirk Höper Rainer G. Ulrich Norbert Nowotny Martin Beer Cecilia Ley Dennis Rubbenstroth Mystery of fatal ‘staggering disease’ unravelled: novel rustrela virus causes severe meningoencephalomyelitis in domestic cats Nature Communications |
| title | Mystery of fatal ‘staggering disease’ unravelled: novel rustrela virus causes severe meningoencephalomyelitis in domestic cats |
| title_full | Mystery of fatal ‘staggering disease’ unravelled: novel rustrela virus causes severe meningoencephalomyelitis in domestic cats |
| title_fullStr | Mystery of fatal ‘staggering disease’ unravelled: novel rustrela virus causes severe meningoencephalomyelitis in domestic cats |
| title_full_unstemmed | Mystery of fatal ‘staggering disease’ unravelled: novel rustrela virus causes severe meningoencephalomyelitis in domestic cats |
| title_short | Mystery of fatal ‘staggering disease’ unravelled: novel rustrela virus causes severe meningoencephalomyelitis in domestic cats |
| title_sort | mystery of fatal staggering disease unravelled novel rustrela virus causes severe meningoencephalomyelitis in domestic cats |
| url | https://doi.org/10.1038/s41467-023-36204-w |
| work_keys_str_mv | AT kasparmatiasek mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT florianpfaff mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT herbertweissenbock mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT claudiawylezich mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT jolantakolodziejek mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT sofiatengstrand mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT fraukeecke mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT sinanippert mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT philipstarcky mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT benediktlitz mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT jasminnessler mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT peterwohlsein mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT christinabaumbach mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT larsmundhenk mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT andreaaebischer mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT svenreiche mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT piaweidinger mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT karinmolofsson mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT ceciliarohdin mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT christianeweissenbacherlang mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT juliamatt mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT marcorosati mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT thomasflegel mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT birgerhornfeldt mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT dirkhoper mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT rainergulrich mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT norbertnowotny mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT martinbeer mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT cecilialey mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats AT dennisrubbenstroth mysteryoffatalstaggeringdiseaseunravellednovelrustrelaviruscausesseveremeningoencephalomyelitisindomesticcats |