A Novel CRISPR/Cas9-mediated Mouse Model of Colon CarcinogenesisSummary

A Novel CRISPR/Cas9-mediated Mouse Model of Colon CarcinogenesisSummary

Background & Aims: Human sporadic colorectal cancer (CRC) results from a multistep pathway with sequential acquisition of specific genetic mutations in the colorectal epithelium. Modeling CRC in vivo is critical for understanding the tumor microenvironment. To accurately recapitulate human C...

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Bibliographic Details
Main Authors: Hajime Kashima, Anthony Fischer, Daniel A. Veronese-Paniagua, Vered A. Gazit, Changqing Ma, Yan Yan, Marc S. Levin, Blair B. Madison, Deborah C. Rubin
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Colorectal Neoplasia
CRISPR/Cas9
Mouse Models
PLAGL2
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X24001450

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http://www.sciencedirect.com/science/article/pii/S2352345X24001450

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