Design, synthesis and anticancer evaluation of polymethoxy aurones as potential cell cycle inhibitors

Design, synthesis and anticancer evaluation of polymethoxy aurones as potential cell cycle inhibitors

Background: Cancer is the most fatal disease in humans and the aberrant activity of various cell cycle proteins results in uncontrolled tumor cell proliferation, thus, regulating the cell cycle is an attractive target in cancer therapy. Objectives: Aurone is a naturally occurring active compound wit...

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Bibliographic Details
Main Authors: Zheng Wu, Yaoyao Han, Xiaolan Li, Qiuping Zhang, Renjin Deng, Hong Ren, Wenjing He, Xinduo Wu, Hongwei Guo, Dan Zhu
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Heliyon
Subjects:
Polymethoxy aurones
Prostate cancer
Cell cycle
CyclinB1/CDK1 inhibitor
Network pharmacology
Molecular docking
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023082622

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http://www.sciencedirect.com/science/article/pii/S2405844023082622

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