An oligosaccharyltransferase from Leishmania donovani increases the N-glycan occupancy on plant-produced IgG1

An oligosaccharyltransferase from Leishmania donovani increases the N-glycan occupancy on plant-produced IgG1

N-Glycosylation of immunoglobulin G1 (IgG1) at the heavy chain Fc domain (Asn297) plays an important role for antibody structure and effector functions. While numerous recombinant IgG1 antibodies have been successfully expressed in plants, they frequently display a considerable amount (up to 50%) of...

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Bibliographic Details
Main Authors: Gernot Beihammer, Julia König-Beihammer, Benjamin Kogelmann, Valentina Ruocco, Clemens Grünwald-Gruber, Marc-André D’Aoust, Pierre-Olivier Lavoie, Pooja Saxena, Johannes S. Gach, Herta Steinkellner, Richard Strasser
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Plant Science
Subjects:
antibody
glycoprotein
glycosylation
Nicotiana benthamiana
recombinant protein
Online Access:https://www.frontiersin.org/articles/10.3389/fpls.2023.1233666/full

Internet

https://www.frontiersin.org/articles/10.3389/fpls.2023.1233666/full

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