Site-directed spin labeling reveals pentameric ligand-gated ion channel gating motions.

Site-directed spin labeling reveals pentameric ligand-gated ion channel gating motions.

Pentameric ligand-gated ion channels (pLGICs) are neurotransmitter-activated receptors that mediate fast synaptic transmission. In pLGICs, binding of agonist to the extracellular domain triggers a structural rearrangement that leads to the opening of an ion-conducting pore in the transmembrane domai...

Full description

Bibliographic Details
Main Authors: Cosma D Dellisanti, Borna Ghosh, Susan M Hanson, James M Raspanti, Valerie A Grant, Gaoussou M Diarra, Abby M Schuh, Kenneth Satyshur, Candice S Klug, Cynthia Czajkowski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-11-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC3833874?pdf=render

Internet

http://europepmc.org/articles/PMC3833874?pdf=render

Similar Items