A GIP receptor agonist exhibits beta-cell anti-apoptotic actions in rat models of diabetes resulting in improved beta-cell function and glycemic control.

A GIP receptor agonist exhibits beta-cell anti-apoptotic actions in rat models of diabetes resulting in improved beta-cell function and glycemic control.

AIMS:The gastrointestinal hormone GIP promotes pancreatic islet function and exerts pro-survival actions on cultured beta-cells. However, GIP also promotes lipogenesis, thus potentially restricting its therapeutic use. The current studies evaluated the effects of a truncated GIP analog, D-Ala(2)-GIP...

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Bibliographic Details
Main Authors: Scott B Widenmaier, Su-Jin Kim, Gary K Yang, Thomas De Los Reyes, Cuilan Nian, Ali Asadi, Yutaka Seino, Timothy J Kieffer, Yin Nam Kwok, Christopher H S McIntosh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2834736?pdf=render

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http://europepmc.org/articles/PMC2834736?pdf=render

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