Modulating Nucleus Oxygen Concentration by Altering Intramembrane Cholesterol Levels: Creating Hypoxic Nucleus in Oxic Conditions

Modulating Nucleus Oxygen Concentration by Altering Intramembrane Cholesterol Levels: Creating Hypoxic Nucleus in Oxic Conditions

We propose a novel mechanism by which cancer cells can modulate the oxygen concentration within the nucleus, potentially creating low nuclear oxygen conditions without the need of an hypoxic micro-environment and suited for allowing cancer cells to resist chemo- and radio-therapy. The cells ability...

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Bibliographic Details
Main Authors: Joao Seco, Clarence C. King, Gianmarco Camazzola, Jeannette Jansen, Luca Tirinato, Maria G. Marafioti, Rachel Hanley, Francesca Pagliari, Scott P. Beckman
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
nucleus oxygen concentration
cholesterol
OER
hypoxia
HIF
Warburg Effect
Online Access:https://www.mdpi.com/1422-0067/23/9/5077

Internet

https://www.mdpi.com/1422-0067/23/9/5077

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