Conifer: clonal tree inference for tumor heterogeneity with single-cell and bulk sequencing data

Conifer: clonal tree inference for tumor heterogeneity with single-cell and bulk sequencing data

Abstract Background Genetic heterogeneity of a cancer tumor that develops during clonal evolution is one of the reasons for cancer treatment failure, by increasing the chance of drug resistance. Clones are cell populations with different genotypes, resulting from differences in somatic mutations tha...

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Bibliographic Details
Main Authors: Leila Baghaarabani, Sama Goliaei, Mohammad-Hadi Foroughmand-Araabi, Seyed Peyman Shariatpanahi, Bahram Goliaei
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Bioinformatics
Subjects:
Heterogeneity of tumor
Clonal tree
Bulk sequencing
Single-cell sequencing
Bayesian nonparametric model
Online Access:https://doi.org/10.1186/s12859-021-04338-7

Internet

https://doi.org/10.1186/s12859-021-04338-7

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