MME+ fibro-adipogenic progenitors are the dominant adipogenic population during fatty infiltration in human skeletal muscle

MME+ fibro-adipogenic progenitors are the dominant adipogenic population during fatty infiltration in human skeletal muscle

Using single nuclei and single cell RNA-seq, 3 FAP cell subpopulations are identified in human skeletal muscle, with an MME+ subset showing increased adipogenic potential under fatty infiltration conditions.

Bibliographische Detailangaben
Hauptverfasser: Gillian Fitzgerald, Guillermo Turiel, Tatiane Gorski, Inés Soro-Arnaiz, Jing Zhang, Nicola C. Casartelli, Evi Masschelein, Nicola A. Maffiuletti, Reto Sutter, Michael Leunig, Jean Farup, Katrien De Bock
Format: Artikel
Sprache:English
Veröffentlicht: Nature Portfolio 2023-01-01
Schriftenreihe:Communications Biology
Online Zugang:https://doi.org/10.1038/s42003-023-04504-y

Online

https://doi.org/10.1038/s42003-023-04504-y

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