Dosage-sensitive genes in evolution and disease
Abstract For a subset of genes in our genome a change in gene dosage, by duplication or deletion, causes a phenotypic effect. These dosage-sensitive genes may confer an advantage upon copy number change, but more typically they are associated with disease, including heart disease, cancers and neurop...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-09-01
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| Series: | BMC Biology |
| Online Access: | http://link.springer.com/article/10.1186/s12915-017-0418-y |