Combined Inactivation of Pocket Proteins and APC/C<sup>Cdh1</sup> by Cdk4/6 Controls Recovery from DNA Damage in G1 Phase

Combined Inactivation of Pocket Proteins and APC/C<sup>Cdh1</sup> by Cdk4/6 Controls Recovery from DNA Damage in G1 Phase

Most Cyclin-dependent kinases (Cdks) are redundant for normal cell division. Here we tested whether these redundancies are maintained during cell cycle recovery after a DNA damage-induced arrest in G1. Using non-transformed RPE-1 cells, we find that while Cdk4 and Cdk6 act redundantly during normal...

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Bibliographic Details
Main Authors: Indra A. Shaltiel, Alba Llopis, Melinda Aprelia, Rob Klompmaker, Apostolos Menegakis, Lenno Krenning, René H. Medema
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cells
Subjects:
cell cycle
checkpoint
CDKs
DNA damage
recovery
G1
Online Access:https://www.mdpi.com/2073-4409/10/3/550

Internet

https://www.mdpi.com/2073-4409/10/3/550

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