miR-34a repression in proneural malignant gliomas upregulates expression of its target PDGFRA and promotes tumorigenesis.

miR-34a repression in proneural malignant gliomas upregulates expression of its target PDGFRA and promotes tumorigenesis.

Glioblastoma (GBM) and other malignant gliomas are aggressive primary neoplasms of the brain that exhibit notable refractivity to standard treatment regimens. Recent large-scale molecular profiling has revealed distinct disease subclasses within malignant gliomas whose defining genomic features high...

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Bibliographic Details
Main Authors: Joachim Silber, Anders Jacobsen, Tatsuya Ozawa, Girish Harinath, Alicia Pedraza, Chris Sander, Eric C Holland, Jason T Huse
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3313940?pdf=render

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http://europepmc.org/articles/PMC3313940?pdf=render

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