Oncogenic KSHV-encoded interferon regulatory factor upregulates HMGB2 and CMPK1 expression to promote cell invasion by disrupting a complex lncRNA-OIP5-AS1/miR-218-5p network.

Kaposi's sarcoma (KS), a highly disseminated tumor of hyperproliferative spindle endothelial cells, is the most common AIDS-associated malignancy caused by infection of Kaposi's sarcoma-associated herpesvirus (KSHV). KSHV-encoded viral interferon regulatory factor 1 (vIRF1) is a viral onco...

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Bibliographic Details
Main Authors: Wan Li, Qingxia Wang, Qi Feng, Fei Wang, Qin Yan, Shou-Jiang Gao, Chun Lu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007578