Vitamin D Deficiency Induces Chronic Pain and Microglial Phenotypic Changes in Mice

Vitamin D Deficiency Induces Chronic Pain and Microglial Phenotypic Changes in Mice

The bioactive form of vitamin D, 1,25-dihydroxyvitamin D (1,25D3), exerts immunomodulatory actions resulting in neuroprotective effects potentially useful against neurodegenerative and autoimmune diseases. In fact, vitamin D deficiency status has been correlated with painful manifestations associate...

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Bibliographic Details
Main Authors: Nicola Alessio, Carmela Belardo, Maria Consiglia Trotta, Salvatore Paino, Serena Boccella, Francesca Gargano, Gorizio Pieretti, Flavia Ricciardi, Ida Marabese, Livio Luongo, Umberto Galderisi, Michele D’Amico, Sabatino Maione, Francesca Guida
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
microglia
vitamin D deficiency
chronic pain
gender
palmitoylethanolamide
Online Access:https://www.mdpi.com/1422-0067/22/7/3604

Internet

https://www.mdpi.com/1422-0067/22/7/3604

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