Novel αO-conotoxin GeXIVA[1,2] Nonaddictive Analgesic with Pharmacokinetic Modelling-Based Mechanistic Assessment

Novel αO-conotoxin GeXIVA[1,2] Nonaddictive Analgesic with Pharmacokinetic Modelling-Based Mechanistic Assessment

αO-conotoxin GeXIVA[1,2] was isolated in our laboratory from <i>Conus generalis</i><i>, </i>a snail native to the South China Sea, and is a novel, nonaddictive, intramuscularly administered analgesic targeting the α9α10 nicotinic acetylcholine receptor (nAChR) with an IC<s...

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Bibliographic Details
Main Authors: Xiaoyu Zhu, Mei Yuan, Huanbai Wang, Dongting Zhangsun, Gang Yu, Jinjing Che, Sulan Luo
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pharmaceutics
Subjects:
αO-conotoxin GeXIVA[1,2]
nonaddictive analgesic
α9α10 nAChR inhibitor
pharmacokinetics
PopPK and PK-PD modelling
mechanism
Online Access:https://www.mdpi.com/1999-4923/14/9/1789

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https://www.mdpi.com/1999-4923/14/9/1789

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