Biophysical Evaluation of Rhesus Macaque Fc Gamma Receptors Reveals Similar IgG Fc Glycoform Preferences to Human Receptors

Biophysical Evaluation of Rhesus Macaque Fc Gamma Receptors Reveals Similar IgG Fc Glycoform Preferences to Human Receptors

Rhesus macaques are a common non-human primate model used in the evaluation of human monoclonal antibodies, molecules whose effector functions depend on a conserved N-linked glycan in the Fc region. This carbohydrate is a target of glycoengineering efforts aimed at altering antibody effector functio...

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Bibliographic Details
Main Authors: Andrew R. Crowley, Nana Yaw Osei-Owusu, Gillian Dekkers, Wenda Gao, Manfred Wuhrer, Diogo M. Magnani, Keith A. Reimann, Seth H. Pincus, Gestur Vidarsson, Margaret E. Ackerman
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
nonhuman primate
IgG
Fc gamma receptor
N glycan
rhesus macaque
ADCC - antibody dependent cellular cytotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.754710/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.754710/full

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