A Combination of Podophyllotoxin and Rutin Alleviates Radiation-Induced Pneumonitis and Fibrosis through Modulation of Lung Inflammation in Mice

A Combination of Podophyllotoxin and Rutin Alleviates Radiation-Induced Pneumonitis and Fibrosis through Modulation of Lung Inflammation in Mice

Pneumonitis and pulmonary fibrosis are predominant consequences of radiation exposure, whether planned or accidental. The present study, demonstrates radioprotective potential of a formulation, prepared by combining podophyllotoxin and rutin (G-003M), in mice exposed to 11 Gy thoracic gamma radiatio...

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Bibliographic Details
Main Authors: Savita Verma, Bhargab Kalita, Sania Bajaj, Hridayesh Prakash, Ajay Kumar Singh, Manju Lata Gupta
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
podophyllotoxin
rutin
pneumonitis
pulmonary fibrosis
inflammation
reactive oxygen species
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00658/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00658/full

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