Preferential selection of viral escape mutants by CD8+ T cell 'sieving' of SIV reactivation from latency.

Preferential selection of viral escape mutants by CD8+ T cell 'sieving' of SIV reactivation from latency.

HIV rapidly rebounds after interruption of antiretroviral therapy (ART). HIV-specific CD8+ T cells may act to prevent early events in viral reactivation. However, the presence of viral immune escape mutations may limit the effect of CD8+ T cells on viral rebound. Here, we studied the impact of CD8 i...

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Bibliographic Details
Main Authors: Steffen S Docken, Kevin McCormick, M Betina Pampena, Sadia Samer, Emily Lindemuth, Mykola Pinkevych, Elise G Viox, Yuhuang Wu, Timothy E Schlub, Deborah Cromer, Brandon F Keele, Mirko Paiardini, Michael R Betts, Katharine J Bar, Miles P Davenport
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-11-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011755&type=printable

Internet

https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011755&type=printable

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