Baicalein targets CD36 to prevent foam cell formation by suppressing the excessive uptake of oxLDL and accelerating ABCA1-mediated cholesterol efflux in oxLDL-induced THP-1 macrophages

Baicalein targets CD36 to prevent foam cell formation by suppressing the excessive uptake of oxLDL and accelerating ABCA1-mediated cholesterol efflux in oxLDL-induced THP-1 macrophages

Oxidized low-density lipoprotein (oxLDL)-induced macrophage foam cell formation plays an important role in atherosclerosis progression. Baicalein is a constituent of Scutellaria baicalensis. Herein, we investigated the effect of baicalein on macrophage foam cell formation and the underlying mechanis...

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Bibliographic Details
Main Authors: Jingda Li, Tao Xiong, Tianqi Wang, Meng Wang, Chao Wang, Fuyuan Yang, Xudong Wang, Zhijian Tan, Wenlong Sun
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Journal of Functional Foods
Subjects:
Baicalein
CD36
Oxidized low-density lipoprotein
ABCA1
Cholesterol efflux
Macrophage foam cell formation
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464622003231

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http://www.sciencedirect.com/science/article/pii/S1756464622003231

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