Huntington disease iPSCs show early molecular changes in intracellular signaling, the expression of oxidative stress proteins and the p53 pathway

Huntington disease iPSCs show early molecular changes in intracellular signaling, the expression of oxidative stress proteins and the p53 pathway

Huntington disease (HD) is a brain disorder characterized by the late onset of motor and cognitive symptoms, even though the neurons in the brain begin to suffer dysfunction and degeneration long before symptoms appear. There is currently no cure. Several molecular and developmental effects of HD ha...

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Bibliographic Details
Main Authors: Wojciech J. Szlachcic, Pawel M. Switonski, Wlodzimierz J. Krzyzosiak, Marek Figlerowicz, Maciej Figiel
Format: Article
Language:English
Published: The Company of Biologists 2015-09-01
Series:Disease Models & Mechanisms
Subjects:
Huntington disease
MAPK pathway
SOD1
Wnt pathway
iPS
iPSC
p53 pathway
Online Access:http://dmm.biologists.org/content/8/9/1047

Internet

http://dmm.biologists.org/content/8/9/1047

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