Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1

Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1

Abstract Background Itch is an unpleasant sensation that can be debilitating, especially if it is chronic and of non-histaminergic origin, as treatment options are limited. Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor that also has the ability to induce a burning, non-histaminergic pru...

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Bibliographic Details
Main Authors: Elín I. Magnúsdóttir, Mirjana Grujic, Jessica Bergman, Gunnar Pejler, Malin C. Lagerström
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Neuroinflammation
Subjects:
Itch
Chymase
Carboxypeptidase A3
Tryptase
Mice
Online Access:http://link.springer.com/article/10.1186/s12974-020-01795-4

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http://link.springer.com/article/10.1186/s12974-020-01795-4

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