Dissection of a Krox20 positive feedback loop driving cell fate choices in hindbrain patterning

Dissection of a Krox20 positive feedback loop driving cell fate choices in hindbrain patterning

Although feedback loops are essential in development, their molecular implementation and precise functions remain elusive. Using enhancer knockout in mice, we demonstrate that a direct, positive autoregulatory loop amplifies and maintains the expression of Krox20, a transcription factor governing ve...

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Bibliographic Details
Main Authors: Yassine X Bouchoucha, Jürgen Reingruber, Charlotte Labalette, Michel A Wassef, Elodie Thierion, Carole Desmarquet‐Trin Dinh, David Holcman, Pascale Gilardi‐Hebenstreit, Patrick Charnay
Format: Article
Language:English
Published: Springer Nature 2013-01-01
Series:Molecular Systems Biology
Subjects:
Fgf
Krox20
rhombomere
stochastic model
transcriptional enhancer
Online Access:https://doi.org/10.1038/msb.2013.46

Internet

https://doi.org/10.1038/msb.2013.46

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