Multi-modal Single-Cell Analysis Reveals Brain Immune Landscape Plasticity during Aging and Gut Microbiota Dysbiosis

Summary: Phenotypic and functional plasticity of brain immune cells contribute to brain tissue homeostasis and disease. Immune cell plasticity is profoundly influenced by tissue microenvironment cues and systemic factors. Aging and gut microbiota dysbiosis that reshape brain immune cell plasticity a...

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Bibliographic Details
Main Authors: Samantha M. Golomb, Ian H. Guldner, Anqi Zhao, Qingfei Wang, Bhavana Palakurthi, Emilija A. Aleksandrovic, Jacqueline A. Lopez, Shaun W. Lee, Kai Yang, Siyuan Zhang
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720314273