Synthesis and preclinical evaluation of [11C]EAI045 as a PET tracer for imaging tumors expressing mutated epidermal growth factor receptor

Synthesis and preclinical evaluation of [11C]EAI045 as a PET tracer for imaging tumors expressing mutated epidermal growth factor receptor

Abstract Background Mutations in the epidermal growth factor receptor (EGFR) kinase domain are common in non-small cell lung cancer. Conventional tyrosine kinase inhibitors target the mutation site in the ATP binding pocket, thereby inhibiting the receptor's function. However, subsequent treatm...

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Bibliographic Details
Main Authors: Antonia A. Högnäsbacka, Alex J. Poot, Christophe Plisson, Jonas Bergare, David R. Bonsall, Stuart P. McCluskey, Lisa A. Wells, Esther Kooijman, Robert C. Schuit, Mariska Verlaan, Wissam Beaino, Guus A. M. S. van Dongen, Danielle J. Vugts, Charles S. Elmore, Jan Passchier, Albert D. Windhorst
Format: Article
Language:English
Published: SpringerOpen 2024-02-01
Series:EJNMMI Research
Subjects:
EAI045
Epidermal growth factor receptor
EGFR
Tyrosine kinase inhibitor
TKI
Online Access:https://doi.org/10.1186/s13550-024-01078-6

Internet

https://doi.org/10.1186/s13550-024-01078-6

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