Inhibition of the norA gene expression and the NorA efflux pump by the tannic acid

Abstract The NorA efflux pump of Staphylococcus aureus is known to play a major role in the development of resistance against quinolone drugs by reducing their concentration inside target pathogens. The objective of this study was to evaluate the ability of tannic acid to inhibit the gene expression...

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Main Authors: Saulo Relison Tintino, Polrat Wilairatana, Veruska Cintia Alexandrino de Souza, Julia Mariana Assis da Silva, Pedro Silvino Pereira, Cícera Datiane de Morais Oliveira-Tintino, Yedda Maria Lobo Soares de Matos, João Tavares Calixto Júnior, Valdir de Queiroz Balbino, José P. Siqueira-Junior, Irwin Rose Alencar Menezes, Abolghasem Siyadatpanah, Henrique Douglas Melo Coutinho, Tereza Cristina Leal Balbino
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-43038-5