A gene cluster in Ginkgo biloba encodes unique multifunctional cytochrome P450s that initiate ginkgolide biosynthesis

Although ginkgo terpenoids have been studied extensively for their pharmaceutical properties, knowledge on their biosynthesis remains limited. Here, the authors identify five multifunctional cytochrome P450s that catalyze the generation of the tert-butyl group and one of the lactone rings towards th...

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Bibliographic Details
Main Authors: Victor Forman, Dan Luo, Fernando Geu-Flores, René Lemcke, David R. Nelson, Sotirios C. Kampranis, Dan Staerk, Birger Lindberg Møller, Irini Pateraki
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32879-9