Structural insights into the mechanism of GTP initiation of microtubule assembly

Structural insights into the mechanism of GTP initiation of microtubule assembly

Abstract In eukaryotes, the dynamic assembly of microtubules (MT) plays an important role in numerous cellular processes. The underlying mechanism of GTP triggering MT assembly is still unknown. Here, we present cryo-EM structures of tubulin heterodimer at their GTP- and GDP-bound states, intermedia...

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Bibliographic Details
Main Authors: Ju Zhou, Anhui Wang, Yinlong Song, Nan Liu, Jia Wang, Yan Li, Xin Liang, Guohui Li, Huiying Chu, Hong-Wei Wang
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41615-w

Internet

https://doi.org/10.1038/s41467-023-41615-w

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