Systemic application of bone-targeting peptidoglycan hydrolases as a novel treatment approach for staphylococcal bone infection

Systemic application of bone-targeting peptidoglycan hydrolases as a novel treatment approach for staphylococcal bone infection

ABSTRACT The current standard of treatment for chronic staphylococcal osteomyelitis entails high doses of antibiotics over the course of several weeks. Biofilm-associated and intracellular persisters are key factors contributing to therapeutic failure. Additionally, systemic application results in l...

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Bibliographic Details
Main Authors: Anja P. Keller, Markus Huemer, Chun-Chi Chang, Srikanth Mairpady Shambat, Caroline Bjurnemark, Nicole Oberortner, Michaela V. Santschi, Léa V. Zinsli, Christian Röhrig, Anna M. Sobieraj, Yang Shen, Fritz Eichenseher, Annelies S. Zinkernagel, Martin J. Loessner, Mathias Schmelcher
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
antibiotic resistance
bacteriophages
phage display
cell-penetrating homing peptide
endolysin
MRSA
Online Access:https://journals.asm.org/doi/10.1128/mbio.01830-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01830-23

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