Distinct Bile Acid Profiles in Patients With Chronic Hepatitis B Virus Infection Reveal Metabolic Interplay Between Host, Virus and Gut Microbiome

Distinct Bile Acid Profiles in Patients With Chronic Hepatitis B Virus Infection Reveal Metabolic Interplay Between Host, Virus and Gut Microbiome

Hepatitis B virus (HBV) can hijack the host bile acids (BAs) metabolic pathway during infection in cell and animal models. Additionally, microbiome was known to play critical role in the enterohepatic cycle of BAs. However, the impact of HBV infection and associated gut microbiota on the BA metaboli...

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Bibliographic Details
Main Authors: Zeyu Sun, Chenjie Huang, Yixian Shi, Rusha Wang, Jun Fan, Ye Yu, Zhehua Zhang, Kundan Zhu, Minwei Li, Qin Ni, Zhi Chen, Min Zheng, Zhenggang Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Medicine
Subjects:
chronic hepatitis B
metabolomics
bile acid metabolism
gut microbiome
NTCP
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.708495/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.708495/full

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