An Angiopep2-PAPTP Construct Overcomes the Blood-Brain Barrier. New Perspectives against Brain Tumors

An Angiopep2-PAPTP Construct Overcomes the Blood-Brain Barrier. New Perspectives against Brain Tumors

A developing family of chemotherapeutics—derived from 5-(4-phenoxybutoxy)psoralen (PAP-1)—target mitochondrial potassium channel mtKv1.3 to selectively induce oxidative stress and death of diseased cells. The key to their effectiveness is the presence of a positively charged triphenylphosphonium gro...

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Bibliographic Details
Main Authors: Sofia Parrasia, Andrea Rossa, Tatiana Varanita, Vanessa Checchetto, Riccardo De Lorenzi, Mario Zoratti, Cristina Paradisi, Paolo Ruzza, Andrea Mattarei, Ildikò Szabò, Lucia Biasutto
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Pharmaceuticals
Subjects:
PAPTP
Angiopep-2
blood-brain barrier
brain delivery
glioma
Online Access:https://www.mdpi.com/1424-8247/14/2/129

Internet

https://www.mdpi.com/1424-8247/14/2/129

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