ATP Releasing Connexin 30 Hemichannels Mediate Flow-Induced Calcium Signaling in the Collecting Duct

ATP Releasing Connexin 30 Hemichannels Mediate Flow-Induced Calcium Signaling in the Collecting Duct

ATP in the renal tubular fluid is an important regulator of salt and water reabsorption via purinergic calcium signaling that involves the P2Y2 receptor, ENaC and AQP2. Recently, we have shown that connexin (Cx) 30 hemichannels are localized to the non-junctional apical membrane of cells in the dist...

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Bibliographic Details
Main Authors: Per eSvenningsen, James eBurford, Janos ePeti-Peterdi
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-10-01
Series:Frontiers in Physiology
Subjects:
calcium imaging
connexin
ATP release
hemichannels
intravital fluorescence microscopy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00292/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00292/full

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