Delivery of IL-2 to the T Cell Surface Through Phosphatidylserine Permits Robust Expansion of CD8 T Cells

Delivery of IL-2 to the T Cell Surface Through Phosphatidylserine Permits Robust Expansion of CD8 T Cells

The phospholipid phosphatidylserine (PS) is naturally maintained on the cytoplasmic side of the plasma membrane. Independent of apoptosis, PS is redistributed to the surface of CD8 T cells in response to TCR-mediated activation. Annexin V (AnnV) is a protein known to bind PS with high affinity and h...

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Bibliographic Details
Main Authors: Alana MacDonald, Brandon Lam, John Lin, Louise Ferrall, Yu Jui Kung, Ya Chea Tsai, T.-C. Wu, Chien-Fu Hung
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
phosphatidylserine (PS)
annexin V
interleukin 2 (IL 2)
CD8 T cells
activation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.755995/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.755995/full

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