Persistence of Coxsackievirus B4 in Pancreatic β Cells Disturbs Insulin Maturation, Pattern of Cellular Proteins, and DNA Methylation

Persistence of Coxsackievirus B4 in Pancreatic β Cells Disturbs Insulin Maturation, Pattern of Cellular Proteins, and DNA Methylation

Coxsackievirus-B4 (CV-B4) can persist in pancreatic cell lines and impair the phenoytpe and/or gene expressions in these cells; however, the models used to study this phenomenon did not produce insulin. Therefore, we investigated CV-B4 persistence and its consequences in insulin-producing pancreatic...

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Bibliographic Details
Main Authors: Magloire Pandoua Nekoua, Antoine Bertin, Famara Sane, Jean-Pascal Gimeno, Isabelle Fournier, Michel Salzet, Ilka Engelmann, Enagnon Kazali Alidjinou, Didier Hober
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Microorganisms
Subjects:
coxsackievirus B4
persistence
insulin
pro-hormone convertase 2
DNA methylation
pancreatic β cell
Online Access:https://www.mdpi.com/2076-2607/9/6/1125

Internet

https://www.mdpi.com/2076-2607/9/6/1125

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