Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists
The interferon (IFN) induced anti-viral response is amongst the earliest and most potent of the innate responses to fight viral infection. The induction of the Janus kinase/signal transducer and activation of transcription (JAK/STAT) signalling pathway by IFNs leads to the upregulation of hundreds o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-06-01
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| Series: | Vaccines |
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| Online Access: | http://www.mdpi.com/2076-393X/4/3/23 |