CircFOXO3 protects against osteoarthritis by targeting its parental gene FOXO3 and activating PI3K/AKT-mediated autophagy

CircFOXO3 protects against osteoarthritis by targeting its parental gene FOXO3 and activating PI3K/AKT-mediated autophagy

Abstract Osteoarthritis (OA) is a degenerative joint disorder causing pain and functional disability. Emerging evidence reveals that circular RNAs (circRNAs) play essential roles in OA progression and development. This study aimed to investigate the role of a novel circRNA factor, circFOXO3, in the...

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Bibliographic Details
Main Authors: Chen Zhao, Xiaodong Li, Guantong Sun, Pengcheng Liu, Keyu Kong, Xuzhuo Chen, Fei Yang, Xiaoqing Wang
Format: Article
Language:English
Published: Nature Publishing Group 2022-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05390-8

Internet

https://doi.org/10.1038/s41419-022-05390-8

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