Assessment of lipophilicity of newly synthesized celecoxib analogues using reversed-phase HPLC

Assessment of lipophilicity of newly synthesized celecoxib analogues using reversed-phase HPLC

Abstract Background Lipophilicity is a physicochemical property of an essential importance in medicinal chemistry; therefore, fast and reliable measurement of lipophilicity will affect greatly the drug discovery process. Results A series of N-benzenesulfonamide-1H-pyrazoles, oximes and hydrazones as...

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Bibliographic Details
Main Authors: Heba Elmansi, Jenny Jeehan Nasr, Azza H. Rageh, Mohamed I. El-Awady, Ghada S. Hassan, Hatem A. Abdel-Aziz, Fathalla Belal
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Chemistry
Subjects:
Lipophilicity estimation
Celecoxib analogues
HPLC
Lipophilicity chromatographic index
log k w
Online Access:http://link.springer.com/article/10.1186/s13065-019-0607-6

Internet

http://link.springer.com/article/10.1186/s13065-019-0607-6

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