<italic toggle="yes">Entamoeba histolytica</italic>-Induced Mucin Exocytosis Is Mediated by VAMP8 and Is Critical in Mucosal Innate Host Defense

<italic toggle="yes">Entamoeba histolytica</italic>-Induced Mucin Exocytosis Is Mediated by VAMP8 and Is Critical in Mucosal Innate Host Defense

ABSTRACT Intestinal mucus secretion is critical in maintaining mucosal host defense against a myriad of pathogens by preventing direct association with the epithelium. Entamoeba histolytica specifically binds colonic MUC2 mucin and also induces potent hypersecretion from goblet cells; however, chara...

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Bibliographic Details
Main Authors: Steve Cornick, France Moreau, Herbert Y. Gaisano, Kris Chadee
Format: Article
Language:English
Published: American Society for Microbiology 2017-11-01
Series:mBio
Subjects:
Entamoeba histolytica
exocytosis
goblet cells
gut inflammation
innate immunity
mucin
Online Access:https://journals.asm.org/doi/10.1128/mBio.01323-17

Internet

https://journals.asm.org/doi/10.1128/mBio.01323-17

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