Quantitative understanding of HepaRG cells during drug‐induced intrahepatic cholestasis through changes in bile canaliculi dynamics

Abstract An understanding of the quantitative relationship between bile canaliculus (BC) dynamics and the disruption of tight junctions (TJs) during drug‐induced intrahepatic cholestasis may lead to new strategies aimed at drug development and toxicity testing. To investigate the relationship betwee...

Full description

Bibliographic Details
Main Authors: Rie Sonoi, Yoshihisa Hagihara
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:Pharmacology Research & Perspectives
Subjects:
Online Access:https://doi.org/10.1002/prp2.960