CEACAM1 is a direct SOX10 target and inhibits melanoma immune infiltration and stemness

CEACAM1 is a direct SOX10 target and inhibits melanoma immune infiltration and stemness

Summary: SOX10 is a key regulator of melanoma progression and promotes a melanocytic/differentiated state. Here we identified melanoma cell lines lacking SOX10 expression which retain their in vivo growth capabilities. More importantly, we find that SOX10 can regulate T-cell infiltration in melanoma...

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Bibliographic Details
Main Authors: John Abou-Hamad, Jonathan J. Hodgins, Christiano T. de Souza, Brennan Garland, Cédrik Labrèche, Marie Marotel, Cameron Gibson, Samuel Delisle, Julia Pascoal, Rebecca C. Auer, Michele Ardolino, Luc A. Sabourin
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:iScience
Subjects:
Immunology
Cell biology
Stem cells research
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222017965

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222017965

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