IL-15 Prevents the Development of T-ALL from Aberrant Thymocytes with Impaired DNA Repair Functions and Increased NOTCH1 Activation

IL-15 Prevents the Development of T-ALL from Aberrant Thymocytes with Impaired DNA Repair Functions and Increased NOTCH1 Activation

We previously reported that NOD.<i>Scid</i> mice lacking interleukin-15 (IL-15), or IL-15 receptor alpha-chain, develop T-acute lymphoblastic leukemia (T-ALL). To understand the mechanisms by which IL-15 signaling controls T-ALL development, we studied the thymocyte developmental events...

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Bibliographic Details
Main Authors: Madhuparna Nandi, Amit Ghosh, Sara Ali Akbari, Diwakar Bobbala, Marie-Josée Boucher, Alfredo Menendez, Trang Hoang, Subburaj Ilangumaran, Sheela Ramanathan
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cancers
Subjects:
T cell acute lymphoblastic leukemia
<i>Scid</i>
IL-15
NOTCH1
MS5-DL4
Online Access:https://www.mdpi.com/2072-6694/15/3/671

Internet

https://www.mdpi.com/2072-6694/15/3/671

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