Deficiency of autoimmune regulator impairs the immune tolerance effect of bone marrow-derived dendritic cells in mice

Deficiency of autoimmune regulator impairs the immune tolerance effect of bone marrow-derived dendritic cells in mice

As a transcription factor, autoimmune regulator (Aire) participates in thymic negative selection and maintains immune tolerance mainly by regulating the ectopic expression of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs). Aire is also expressed in dendritic cells (DC...

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Bibliographic Details
Main Authors: Feifei Huo, Dongbei Li, Bo Zhao, Yadong Luo, Bingjie Zhao, Xueyang Zou, Yi Li, Wei Yang
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Autoimmunity
Subjects:
autoimmune regulator
dendritic cells
immune tolerance
tissue-restricted antigens
cd4+ t cell
Online Access:http://dx.doi.org/10.1080/08916934.2017.1422124

Internet

http://dx.doi.org/10.1080/08916934.2017.1422124

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