Adenosine-A2A Receptor Signaling Plays a Crucial Role in Sudden Unexpected Death in Epilepsy

Adenosine-A2A Receptor Signaling Plays a Crucial Role in Sudden Unexpected Death in Epilepsy

Adenosinergic activities are suggested to participate in SUDEP pathophysiology; this study aimed to evaluate the adenosine hypothesis of SUDEP and specifically the role of adenosine A2A receptor (A2AR) in the development of a SUDEP mouse model with relevant clinical features. Using a combined paradi...

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Bibliographic Details
Main Authors: Hai-Ying Shen, Sadie B. Baer, Raey Gesese, John M. Cook, Landen Weltha, Shayla Q. Coffman, Jie Wu, Jiang-Fan Chen, Ming Gao, Teng Ji
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
adenosine A2A receptor
NTS, nucleus tractus solitarius
brainstem
SUDEP (sudden unexplained death in epilepsy)
local field potential
adenosine kinase
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.910535/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.910535/full

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