Inhibition of EZH2 alleviates SAHA-induced senescence-associated secretion phenotype in small cell lung cancer cells

Abstract Chemotherapy has been widely used in small cell lung cancer (SCLC) treatment in the past decades. However, SCLC is easy to recur after chemotherapy. The senescence of cancer cells during chemotherapy is one of the effective therapeutic strategies to inhibit the progression of cancer. Nevert...

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Bibliographic Details
Main Authors: Sun-Hyok Kong, Lie Ma, Qingxia Yuan, Xiangxiang Liu, Yu Han, Weifang Xiang, Dong-Xu Liu, Yu Zhang, Jun Lu
Format: Article
Language:English
Published: Nature Publishing Group 2023-08-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01591-y