Blocking pro-inflammatory platelet-activating factor receptors and activating cell survival pathways: A novel therapeutic strategy in experimental ischemic stroke

Blocking pro-inflammatory platelet-activating factor receptors and activating cell survival pathways: A novel therapeutic strategy in experimental ischemic stroke

OBJECTIVE: Acute ischemic stroke triggers complex neurovascular, neuroinflammatory, and synaptic alterations. This study explores whether blocking pro-inflammatory platelet-activating factor receptor (PAF-R) plus selected docosanoids after middle cerebral artery occlusion (MCAo) would lead to neurol...

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Bibliographic Details
Main Authors: Ludmila Belayev, Andre Obenaus, Pranab K Mukherjee, Eric J Knott, Larissa Khoutorova, Madigan M Reid, Cassia R Roque, Lawrence Nguyen, Jeong Bin Lee, Nicos A Petasis, Reinaldo B Oria, Nicolas G Bazan
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Brain Circulation
Subjects:
docosanoids
ischemia/reperfusion
magnetic resonance imaging
neuroinflammation
platelet-activating factor-receptors antagonist
Online Access:http://www.braincirculation.org/article.asp?issn=2394-8108;year=2020;volume=6;issue=4;spage=260;epage=268;aulast=Belayev

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http://www.braincirculation.org/article.asp?issn=2394-8108;year=2020;volume=6;issue=4;spage=260;epage=268;aulast=Belayev

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