Establishment of Level a In Vitro–In Vivo Correlation (IVIVC) via Extended DoE-IVIVC Model: A Donepezil Case Study

Establishment of Level a In Vitro–In Vivo Correlation (IVIVC) via Extended DoE-IVIVC Model: A Donepezil Case Study

This study aimed to establish an extended design of experiment (DoE)-in vitro in vivo correlation (IVIVC) model that defines the relationship between formulation composition, in vitro dissolution, and in vivo pharmacokinetics. Fourteen sustained-release (SR) tablets of a model drug, donepezil, were...

Full description

Bibliographic Details
Main Authors: Da Young Lee, Soyoung Shin, Tae Hwan Kim, Beom Soo Shin
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Pharmaceutics
Subjects:
level A IVIVC
donepezil
mixture design
population pharmacokinetics
sustained release
prediction of in vivo pharmacokinetics
Online Access:https://www.mdpi.com/1999-4923/14/6/1226

Internet

https://www.mdpi.com/1999-4923/14/6/1226

Similar Items