Role of FLCN Phosphorylation in Insulin‐Mediated mTORC1 Activation and Tumorigenesis

Role of FLCN Phosphorylation in Insulin‐Mediated mTORC1 Activation and Tumorigenesis

Abstract The amino acid‐stimulated Rag GTPase pathway is one of the main pathways that regulate mechanistic target of rapamycin complex 1 (mTORC1) activation and function, but little is known about the effects of growth factors on Rag GTPase‐mediated mTORC1 activation. Here, a highly conserved insul...

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Bibliographic Details
Main Authors: Guoyan Wang, Lei Chen, Xinjian Lei, Senlin Qin, Huijun Geng, Yining Zheng, Chao Xia, Junhu Yao, Tong Meng, Lu Deng
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:Advanced Science
Subjects:
FLCN phosphorylation
insulin
mTORC1
tumorigenesis
Online Access:https://doi.org/10.1002/advs.202206826

Internet

https://doi.org/10.1002/advs.202206826

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