MicroRNA-29a Mitigates Osteoblast Senescence and Counteracts Bone Loss through Oxidation Resistance-1 Control of FoxO3 Methylation

MicroRNA-29a Mitigates Osteoblast Senescence and Counteracts Bone Loss through Oxidation Resistance-1 Control of FoxO3 Methylation

Senescent osteoblast overburden accelerates bone mass loss. Little is understood about microRNA control of oxidative stress and osteoblast senescence in osteoporosis. We revealed an association between microRNA-29a (<i>miR-29a</i>) loss, oxidative stress marker 8-hydroxydeoxyguanosine (8...

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Bibliographic Details
Main Authors: Wei-Shiung Lian, Re-Wen Wu, Yu-Shan Chen, Jih-Yang Ko, Shao-Yu Wang, Holger Jahr, Feng-Sheng Wang
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Antioxidants
Subjects:
microRNA-29a
senescence
osteoporosis
Oxr1
FoxO3
Dnmt3b
Online Access:https://www.mdpi.com/2076-3921/10/8/1248

Internet

https://www.mdpi.com/2076-3921/10/8/1248

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