Inhibition of 15‐hydroxyprostaglandin dehydrogenase protects neurons from ferroptosis in ischemic stroke

Inhibition of 15‐hydroxyprostaglandin dehydrogenase protects neurons from ferroptosis in ischemic stroke

Abstract Ischemic stroke is an acute serious cerebrovascular disease with high mortality and disability. Ferroptosis is an important regulated cell death (RCD) in ischemic stroke. 15‐Hydroxyprostaglandin dehydrogenase (15‐PGDH), a degrading enzyme of prostaglandin E2 (PGE2), is shown to regulate RCD...

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Bibliographic Details
Main Authors: Yunfei Xu, Kexin Li, Yao Zhao, Lin Zhou, Nina He, Haoduo Qiao, Qing Xu, Huali Zhang, Ying Liu, Jie Zhao
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:MedComm
Subjects:
15‐PGDH
ferroptosis
GPX4
ischemic stroke
PGE2
Online Access:https://doi.org/10.1002/mco2.452

Internet

https://doi.org/10.1002/mco2.452

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