Low expression of the dynamic network markers FOS/JUN in pre-deteriorated epithelial cells is associated with the progression of colorectal adenoma to carcinoma

Low expression of the dynamic network markers FOS/JUN in pre-deteriorated epithelial cells is associated with the progression of colorectal adenoma to carcinoma

Abstract Background Deterioration of normal intestinal epithelial cells is crucial for colorectal tumorigenesis. However, the process of epithelial cell deterioration and molecular networks that contribute to this process remain unclear. Methods Single-cell data and clinical information were downloa...

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Bibliographic Details
Main Authors: Xiaoqi Huang, Chongyin Han, Jiayuan Zhong, Jiaqi Hu, Yabin Jin, Qinqin Zhang, Wei Luo, Rui Liu, Fei Ling
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Translational Medicine
Subjects:
Colorectal cancer
Dynamic network biomarker
Epithelial cell deterioration
Pre-deteriorated epithelial cell
FOS/JUN
P53
Online Access:https://doi.org/10.1186/s12967-023-03890-5

Internet

https://doi.org/10.1186/s12967-023-03890-5

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